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Home - Products - Membrane Transporter/Ion Channel - P2X Receptor - AZ10606120 dihydrochloride

AZ10606120 dihydrochloride

CAS No. 607378-18-7

AZ10606120 dihydrochloride( —— )

Catalog No. M26620 CAS No. 607378-18-7

AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AZ10606120 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth.
  • Description
    AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth. AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM and it is little or no effect at other P2XR subtypes.
  • In Vitro
    ——
  • In Vivo
    Animal Model:LPS-induced anhedonia miceDosage:2 mg/kg Administration:i.p., pretreated at 30 min before LPS injection Result:Restored the decline in sucrose consumption, indicated by an sucrose preference test (SPT).
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    P2X Receptor
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    607378-18-7
  • Formula Weight
    495.49
  • Molecular Formula
    C25H36Cl2N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 8.33 mg/mL (16.81 mM)
  • SMILES
    Cl.Cl.OCCNCCNc1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chung HK, et al. Plasma phospholipid arachidonic acid and lignoceric acid are associated with the risk of cardioembolic stroke. Nutr Res. 2015 Nov;35(11):1001-8.
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